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Guarana Caffeine Content: How Much Is in Glyco Defender?
Guarana caffeine content in Glyco Defender is unknown, because the label prints no caffeine amount. Guarana seeds contain caffeine, and many of their effects come from it. Guarana is the 4th blend line, so a dropperful holds at most 3.9 mg of guarana extract, a small weight of any kind.
Written by the Glyco Defender label deskUpdated · 4 min read

How much caffeine is in guarana?
It varies, and the Glyco Defender label does not say. What is known is that guarana seeds contain caffeine and that many of the plant's effects are credited to it (MSKCC, Guarana).
The label lists guarana seed extract in 4th place and gives no milligrams of caffeine. Any number online is a guess.
How much guarana can one dropperful hold?
At most 3.9 mg of extract. The blend weighs 15.47 mg in total, and a 4th-place line cannot weigh more than 15.47 divided by 4.
Caffeine would be only part of that weight, since the extract also holds other plant matter. The label uses a 20:1 extract, which tells you how much seed went in, not how strong it is (Monagas et al., Front Pharmacol 2022). Single weights stay hidden under US blend rules (21 CFR 101.36 (eCFR)).
| Source | Printed caffeine | Context |
|---|---|---|
| Glyco Defender, guarana | Not published | 4th line, at most 3.9 mg of extract |
| Glyco Defender, green tea | Not published | 7th line, at most 2.2 mg of extract |
| FDA benchmark | 400 mg a day | About two to three 12-oz cups of coffee (FDA, Caffeine: how much is too much?) |
Can guarana cause jitters or poor sleep?
It can. Common side effects are nausea and insomnia, and high doses can cause vomiting, heartbeat changes, high blood pressure and seizures (MSKCC, Guarana).
Guarana may not be safe with other stimulants and may raise bleeding risk with blood thinners such as warfarin (MSKCC, Guarana). Too much caffeine of any origin can cause a racing heartbeat, shakiness, anxiety and headache (FDA, Caffeine: how much is too much?).
The sales page promises energy "without stimulant jitters". With guarana and green tea on the label and no caffeine figure, that is a promise you cannot check from the bottle.
If you use a blood thinner, a stimulant or a heart medicine, ask your doctor before adding drops that contain guarana.

Glyco Defender: from $49 a bottle30 mL · 1, 3 or 6 bottles · free US shipping on 6 · 60-day money-back guarantee
See packsHow can you handle caffeine with these drops?
Take them early in the day, count your coffee, and stop if you feel wired. The label gives no time of day, so a fixed morning slot such as breakfast is a sensible choice.
The how to use page covers the routine, and the fit check covers who should ask first.
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FAQ01
Questions about guarana and caffeine
Is guarana stronger than coffee?
Nobody can say from the bottle. The label prints no guarana or caffeine amount, and a dropperful holds at most 3.9 mg of guarana extract.
Who should avoid guarana?
People who are pregnant, nursing, have heart or sleep problems, or take stimulants or blood thinners should ask a provider (FDA, Caffeine: how much is too much?) (MSKCC, Guarana). The label also bars use under age 18.
Does Glyco Defender contain caffeine?
Probably some. Guarana and green tea extract both contain caffeine, but neither amount is printed, so the total is unknown. Count it with your other caffeine.
Who wrote this02
Written and reviewed by
Pages built from the label, the sales page and linked NIH, FDA, CDC, FTC and peer-reviewed sources.
Last updated . Read our editorial standards and how we check reviews. This website is run by a licensed U.S. retail desk for Glyco Defender, not by the manufacturer or the label's distributor. Buying through our order links earns us money.
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